Combining Parthenolide and Sulfasalazine Improves Toxicity to CD200+ LIC Populations in Childhood ALL
نویسندگان
چکیده
منابع مشابه
Diamanti Et Al Ptl Eliminates Lic in Childhood All
Around 20% of children with acute lymphoblastic leukemia (ALL) relapse due to failure to eradicate the disease. Current drug efficacy studies focus on reducing leukemia cell burden. However, if drugs have limited effects on leukemia-initiating cells (LIC), these cells may expand and eventually cause relapse. Parthenolide (PTL) has been shown to cause apoptosis of LIC in acute myeloid leukemia. ...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-115996